Modeling breast cancer progression to bone: how driver mutation order and metabolism matter

A Genetic Interaction Screen for Breast Cancer Progression Driver Genes

Crosstalk between Tumor Cells and Immune System Leads to Epithelial-Mesenchymal Transition Induction and Breast Cancer Progression

Herein, we review the current findings of how a variety of accessory cells could participate in shaping the tumor microenvironment and supporting the mechanisms by which cancer cells undertake the epithelial-mesenchymal transition (EMT). EMT, a complex of phenotypic changes, promotes cancer cell invasion and creates resistance to chemotherapies. Among the accessory cells present in the EMT, imm...

The effect of one additional driver mutation on tumor progression

Tumor growth is caused by the acquisition of driver mutations, which enhance the net reproductive rate of cells. Driver mutations may increase cell division, reduce cell death, or allow cells to overcome density-limiting effects. We study the dynamics of tumor growth as one additional driver mutation is acquired. Our models are based on two-type branching processes that terminate in either tumo...

Regulation of Bone Metabolism

Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...

Breast Cancer Progression Modeling Using Static Sample Data (Supplementary Data)

Mathematically, a cancer progression trajectory can be viewed as a complex manifold with a branching structure embedded in a high-dimensional genomic space. Since only a small fraction of genes may involve in tumor growth and spread, the first step is to identify cancer progression related genes supporting a complex manifold. This problem has been extensively studied in both the statistics and ...